I like that I can have a common orchestra mix all setup and ready to use in any project, already to start sequencing and no mixing needed in LogicPro whatsoever. I use MirPro, all inside VePro, where it has handled better with built in features. What I like about larger instances is that I can mix it in VePro, which I consider an advantage. Its possible still as long as you don't need midi sync for example. I have spent a lot of time trying to figure out ways to use larger single instance with LogicPro.But at the end of the day, I think the work flow considerations are more important, But the very best performance will likely be acheived with one single VePro instance, with a larger thread count configuraiton and allow VePro to manage the threads intelligently. I think that is preferable to the 5-instance method.
Each intance will use 1-2 threads, but each seperate instance will be getting its thread allocated more from the operating system instead of VePro's built in thread-allocation strategies. However if you have, say 100 instances and the thread parameter is set to 1 or 2.then it becomes kind of a moot point. However, in actual practice, not all 5 instances will always be active at once, which means VePro would be underlutilizing threads in each of those instances when not all instances are being used. Then you might have to set the thread count parameter to 1/5 of the value you would use for a single-instance scenario. So if you have, for example, 5 instances on a 12 core machine. When you have multiple instances, under the covers those are basically seperate running instances.and whatever thread-count you configure, will apply to each instance individually. If you have a single instance, then you can configure it to use more threads and that one instance will manage all the threads in the best way possible. The reason is because of the way you can configure the number of threads per instance. VePro server has better performance with either a single instance or many instances, but not in-between.All comments below are merely my own opinion. So recognizing first there is no consensus on the best approach, I will just share my point of view, which is frankly changing day by day.